Fig. 2: Interactions of CORVET functional subunits with the core of the complex. | Nature Communications

Fig. 2: Interactions of CORVET functional subunits with the core of the complex.

From: Structure of the endosomal CORVET tethering complex

Fig. 2

A Model of the CORVET complex viewed from the side in ribbon representation. The low-pass-filtered consensus map is shown by a black outline. The subunits are colored as in Fig. 1. B Zoomed-in view of the Vps33-Vps8-Vps16 interface with Vps8 and Vps18 RING finger domains indicated. C Zoomed-in view of the Vps8 structured hairpin sandwiched between Vps33 and Vps18. D Interactions between the α-solenoids of Vps18 and Vps3. Associated semi-transparent cryo-EM densities are zoned around the molecular models and colored accordingly. E Structural alignment of the CORVET molecular model (pink, this study) with the HOPS model (light green, PDB:7ZU0) viewed from two sides. F Close-up views of C-terminal two-helix bundle and RING finger domains of CORVET Vps8 and Vps18 (top) and HOPS Vps41 and Vps18 (bottom). G Close-up views of C-terminal two-helix bundle and RING finger domains of CORVET Vps3 and Vps11 (top) and HOPS Vps39 and Vps11 (bottom).

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