Fig. 1: Structures of tau PET radiotracers divided into structural scaffolds.
From: Ligand-based design of [18F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies
A Compounds based on the carbazole scaffold of [18F]Tauvid™ (a.k.a., [18F]flortaucipir or [18F]T807) which also include [18F]PI-2620. B Janssen’s naphthalene-pyridine linked scaffolds, as well as [18F]MK-6240 ([18F]florquinitau) and [18F]FDDNP. C [11C]PBB3, [18F]F-PBB3, and [18F]florzolotau ([18F]PM-PBB3, [18F]APN-1607) analogues based on a benzothiazole scaffold. D PET radiotracers based on Oxiant Discovery’s fluoropyridinyl-indole scaffold (OXD analogues) including [18F]OXD-2115 (a.k.a. CBD-2115) and [18F]OXD-2314 (this work).
