Table 1 Inhibition constant (Ki) values (n = 1) of OXD-2115 and analogues vs [3H]OXD-2115 in AD and PSP tissue homogenates to establish inhibition potencies

From: Ligand-based design of [18F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies

  1. Chemdraw Professional 15.0 was used for all physicochemical properties except logD7.4, which was obtained experimentally.
  2. In silico models for predicting BBB permeability included CNS MPO, CNS PET MPO and BBB scores.
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