Fig. 4: Heatmaps of miRNA tissue expression, enriched small molecules mode of action and drug indications predicted by sChemNET for selected miRNAs from Homo sapiens.
From: sChemNET: a deep learning framework for predicting small molecules targeting microRNA function
a miRNAs were ordered using hierarchical clustering based on their z-score expression levels on human tissues from the Tissue Atlas database; Red areas indicate expression and the color is proportional to the z-score. b Enrichment values of drug indications predicted by sChemNET for each miRNA. The color is proportional to the \({-\log }_{10}{adjP}\), where \({{{{\rm{adjP}}}}}\) is the Benjamini-Hochberg corrected p-value calculated using Fisher’s Exact Test to keep an overall significance below 0.05. White areas indicate non-significant; (c) Enrichment values of drug mode of action predicted by sChemNET for each miRNA. The color is proportional to the, where \({{{{\rm{adjP}}}}}\) is the Benjamini–Hochberg corrected p-value calculated using Fisher’s Exact Test to keep an overall significance below 0.05. White areas indicate non-significant.
