Fig. 3: Proteome subtypes of MB can be assigned to two main profiles. | Nature Communications

Fig. 3: Proteome subtypes of MB can be assigned to two main profiles.

From: Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level

Fig. 3

A Proteome cluster similarity hierarchy based on stepwise increasing k-means execution from k = 2–6 with network analyses showing gene set overlap dependent MCL clustering of enriched gene sets, comparing pG3, pG4 and pSHHs (n = 79, profile 1), to pWNT, pG3myc, pSHHt (n = 88, profile 2). Gene set enrichment analysis (GSEA) was based on REACTOME pathways for all analysis. Top two upregulated genesets based on differentially abundant proteins using Ingenuity Pathway Analyses (IPA) in profile 1 (opioid signaling and SNARE complex (two-tailed, unpaired t-test, log2 FC > 1.5 and p value < 0.05)) (B)) and profile 2 (EIF2 signaling and cell cycle control of chromosomal replication (log2 FC > 1.5 and p value < 0.05) (C). IPA-based pathway analyses of opiod signaling (D) and cell cycle control of chromosomal replication (E) indicating therapeutic targets with respective drugs. n represents biologically independent human samples.

Back to article page