Fig. 4: Correlation between DNA methylome and proteome features. | Nature Communications

Fig. 4: Correlation between DNA methylome and proteome features.

From: Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level

Fig. 4

A Circular plot from mixOmics analyses based on selected features of the first five components from proteome and methylome data. The plot illustrates features with correlation r > 0.7 represented on side quadrants. Proteome group-specific feature levels are shown in the outer circle. B Proteome subtype-specific Pearson correlation calculated between matched proteins and CpG methylation sites. The number of proteins correlating with CpG site methylation of their own gene (r > 0.7) is shown in color. The pie chart shows the distribution of correlating CpG sites concerning the position in a gene. C Subtype independent Pearson correlation between 3990 proteins and 381,717 methylation probes focusing on subtype-specific biomarkers. Pearson Correlations >0.7 are shown, CpG sites correlating with the corresponding gene are highlighted in blue. Some biomarkers correlated with more than one CpG site of their own gene (GAB1: 7, GNB3: 2, IGSF21: 3, MICAL1: 3, and PALMD: 2). D Scatterplot of the 10 biomarker proteins correlating with the CpG site(s) of their own gene (Pearson correlation > 0.7, p < 0.001). The linear regression line was aligned for all correlating CpG site(s), SE = 0.95.

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