Table 3 Transcription factor pathways enriched for genes that are upregulated in the pregnant liver

From: A co-ordinated transcriptional programme in the maternal liver supplies long chain polyunsaturated fatty acids to the conceptus using phospholipids

Transcription Factor Pathway

Adjusted P-Value

#Upregulated DEGs (/#All Targets)

LC-PUFA-Phospholipid Pathway DEGs

#

Gene Names

FOXM1

1.05E-11

56/267

0

 

IRF8

1.04E-10

217/2000

0

 

SMRT

2.45E-05

193/2000

0

 

RXR

7.03E-05

190/2000

3

Fads1, Fads2, Pnpla3

LXR

1.33E-04

188/2000

6

Cd36, Fads1, Fads2, Pcyt1a Pnpla3, Mttp

MECOM

2.76E-04

182/1951

0

 

NCOR

4.94E-04

184/2000

0

 

CLOCK

1.71E-02

47/407

0

 

ESR1

1.78E-02

50/444

1

Fads2

IRF8

2.91E-02

38/319

0

 
  1. Overlap analysis between transcription factor targets and upregulated differentially expressed genes (DEGs) generated from the re-analysis of a published whole-transcriptome microarray dataset of livers from pregnant (14.5 dpc) and virgin mice (n = 4 mice per condition), using ChIP enrichment analysis (ChEA) through the Enrichr platform. Enriched DEGs were then searched for LC-PUFA-containing-phospholipid biosynthetic genes of interest. See Supplementary Data Table S11 for the full list of enriched DEGs in each transcription factor pathway. Differential expression analysis was performed using limma with a p-value (corrected for multiple hypothesis testing based on the Benjamini–Hochberg procedure) threshold of 0.05 and a fold change threshold of 1.25 (DEG list is found in Supplementary Data Table S9).
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