Fig. 4: Evaluation of MRS, PRS, and traditional risk factors in the prediction of incident ACS. | Nature Communications

Fig. 4: Evaluation of MRS, PRS, and traditional risk factors in the prediction of incident ACS.

From: Genome-wide DNA methylation profiling in blood reveals epigenetic signature of incident acute coronary syndrome

Fig. 4

a Evaluation in the DFTJ cohort. b Evaluation in the CKB cohort. Traditional risk factors include age, sex, BMI, smoking status, drinking status, hypertension, dyslipidemia, and diabetes. The MRS was calculated by adding the M-values of 67 DMPs identified in the discovery cohort, weighted by their β coefficients from the discovery cohort. ACS acute coronary syndrome, AUC area under ROC curve, DMP differentially methylated position, MRS methylation risk score, PRS polygenic risk score, PRSBBJ published PRS based on the BioBank Japan cohort, PRSCHN published PRS based on Chinese populations, ROC receiver operating characteristic curve.

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