Fig. 6: GV-971 improves SAP-induced dysregulation in peripheral blood.

a Peripheral blood samples were collected from different groups, including control mice (CON, n = 8 samples), mice with SAP (SAP, n = 7 samples), and SAP mice pre-treated with a high dose of GV-971 (HG + SAP, n = 8 samples), and were analyzed using mass cytometry. The viSNE maps are colored by the normalized expression of indicated surface markers in peripheral blood (PB) CD45⁺ cells. b A heatmap displaying the normalized expression of 10 indicated markers in 10 PB cell populations. c These viSNE maps are colored by 11 main cell populations in PB after clustering. d, e Bar plots showing the frequencies of the indicated populations in PB CD45⁺ cells of mice in different groups (CON, n = 8 samples; SAP, n = 7 samples; HG + SAP, n = 8 samples). f A heatmap displaying the normalized expression of eight indicated markers in 11 PB T-cell populations. g These viSNE maps are colored by 11 T-cell subpopulations in all PB T cells after clustering. h Bar plots showing the frequencies of the indicated T-cell subpopulations in PB CD45⁺ cells of mice in different groups (CON, n = 8 samples; SAP, n = 7 samples; HG + SAP, n = 8 samples). Data are presented as mean ± SD. Statistical comparisons were performed using one-way ANOVA with Dunnett’s test for statistical significance. Source data are provided as a Source Data file. DNT double-negative T cell, TCR T-cell receptor, Gran granulocyte, Mono monocytes, DC dendritic cell, r- rest of, Treg regulatory T cell, Th1 T helper 1 cell.