Fig. 6: Schematic diagram of elevated 11β-HSD1 in osteoblasts contributes to HFD-induced bone loss, glucose handling impairment and obesity. | Nature Communications

Fig. 6: Schematic diagram of elevated 11β-HSD1 in osteoblasts contributes to HFD-induced bone loss, glucose handling impairment and obesity.

From: Targeting osteoblastic 11β-HSD1 to combat high-fat diet-induced bone loss and obesity

Fig. 6

In the context of HFD-induced obesity, osteoblastic 11β-HSD1 levels are upregulated, leading to overactivated glucocorticoid (GC) signaling. This augmented GC signaling downregulates the expression of Early Growth Response 2 (Egr2) in osteoblasts, and the suppressed Egr2 further restrains skeletal glucose uptake and bone formation. Consequently, the reduction in skeletal glucose uptake and bone formation contributes to bone loss and glucose handling impairment associated with obesity. This figure was created in BioRender. Zhang, G. (2023) BioRender.com/c52z877.

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