Fig. 2: HURP differentially affects Kif18A motility in a concentration-dependent manner.
From: HURP regulates Kif18A recruitment and activity to synergistically control microtubule dynamics
a Representative kymographs showing the motility of full-length Kif18A and Kif18A1-480 in the presence of 0, 0.1, and 0.5 µM HURP1-846 and 0, 0.5, and 6.5 µM HURP1-285. b Normalized run frequency, velocity, and run time of Kif18A and Kif18A1-480 in the presence of different concentrations of HURP1-285 or HURP1-846. For run frequency, n = 10 microtubules for each condition. For velocity and run time, N = 32, 50, 33, 48, 50, 40, 25, 25, 25, 25, 25, 52, 44, 54, 52, 52, 52, 51, 52, 52, 52 motors, from left to right. In (b), the line and shadows represent the mean and standard error (S.E.), respectively. The in vitro motility assays were performed with 2 technical replicates. Source data are provided as a Source Data file.
