Fig. 5: Synthetic applications and mechanistic studies.
a Product derivatization. b This protocol enables the rapid preparation of saturated bioisosteres of anticancer drug Capesaris. c The radical clock and radical inhibition experiments reveal the involvement of alkyl radical intermediate. d The carbocation pathway is excluded by using water as nucleophile. e Experiments investigating the impact of Et3N suggest its potential role as a protector for both the amine substrate and product, shielding them from decomposition. f The reaction proceeds using stoichiometric metal catalysts even in the absence of electricity. g Prussian Blue detection experiment proved the existence of Fe(III) species. h Cyclic voltammetry experiments indicated that TolNH2 promoted the generation of Cu(II) species, while carboxylic acid facilitated the formation of Fe(III) intermediates (compound concentration:10 mM in DMF, reference Electrode: Ag/AgCl electrode, scan rate:100 mV s–1). i, UV−vis absorption experiments provided further evidence for photoexcited Fe(III) intermediate.
