Fig. 8: Schematic summary illustrating the role of Endocan in GBM-VE crosstalk. | Nature Communications

Fig. 8: Schematic summary illustrating the role of Endocan in GBM-VE crosstalk.

From: Endothelial-secreted Endocan activates PDGFRA and regulates vascularity and spatial phenotype in glioblastoma

Fig. 8

Endocan secreted by VE cells binds to PDGFRA receptor and activates downstream pathway, resulting in upregulated MYC expression and subsequent increase in GBM proliferation, radioresistance, intratumoral heterogeneity and further enhancement of angiogenesis. The figure was created in BioRender. Kornblum, H. (2024) BioRender.com/z54s425.

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