Fig. 8: The role of lipid peroxidation and its key regulator, GPX4, in osteoblasts-mediated bone formation. | Nature Communications

Fig. 8: The role of lipid peroxidation and its key regulator, GPX4, in osteoblasts-mediated bone formation.

From: Regulation of enzymatic lipid peroxidation in osteoblasts protects against postmenopausal osteoporosis

Fig. 8

Phospholipid peroxidation in osteoblasts plays a pivotal role in postmenopausal osteoporosis, driven by diminished estrogen-regulated GPX4 expression. The lipid peroxidation byproduct 4-HNE disrupts RUNX2 signaling through the degradation of ILK. While the natural GPX4 activators 6- and 8-Gingerols promote osteoblastogenesis and demonstrate significant anti-osteoporotic effects.

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