Table 1 Baseline characteristics of participants according to hypertensive disorders of pregnancy genetic risk groups in women from the UK Biobank

From: Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy

 

Low genetic risk ( < 20%)

Intermediate genetic risk (20–80%)

High genetic risk (80–99%)

Very high genetic risk ( > 99%)

P-valuea

No. of participants

(n = 32,900)

(n = 98,700)

(n = 31,255)

(n = 1645)

–

Age, mean (SD), y

57.3 ± 7.7

57.2 ± 7.7

57.2 ± 7.7

57.3 ± 7.6

.213

Number of live births, mean (SD)

2.2 ± 0.9

2.2 ± 0.9

2.2 ± 0.9

2.2 ± 0.9

.766

Body mass index, mean (SD), kg/m2

26.8 ± 4.9

27.1 ± 5.0

27.4 ± 5.2

27.6 ± 5.3

< 2.20E-16

Obesity, No. (%)

–

–

–

–

< 2.20E-16

BMI < 30 kg/m2

25,806 (78.6%)

75,506 (76.7%)

23,247 (74.6%)

1204 (73.4%)

–

BMI ≥ 30 kg/m2

7012 (21.4%)

22,903 (23.3%)

7917 (25.4%)

436 (26.6%)

–

Systolic blood pressure, mean (SD), mmHg

134.0 ± 19.1

136.2 ± 19.2

138.2 ± 19.3

140.7 ± 19.5

< 2.20E-16

Diastolic blood pressure, mean (SD), mmHg

79.5 ± 9.8

80.7 ± 9.9

81.8 ± 9.9

83.0 ± 10.1

< 2.20E-16

Current smoker, No. (%)

2699 (8.2%)

8323 (8.4%)

2707 (8.7%)

146 (8.9%)

< 2.20E-16

Use of aspirin, No. (%)

2967 (9.0%)

10,005 (10.1%)

3543 (11.3%)

200 (12.2%)

< 2.20E-16

Use of antihypertensive medication, No. (%)

4845 (14.7%)

18,667 (18.9%)

7380 (23.6%)

469 (28.5%)

< 2.20E-16

Use of cholesterol medication, No. (%)

4185 (12.7%)

13,821 (14.0%)

5017 (16.1%)

299 (18.2%)

< 2.20E-16

  1. aP-value indicates the significance of the difference between the hypertensive disorders of pregnancy genetic risk groups. P-values were derived from the one-way ANOVA for continuous variables and the chi-squared test for categorical variables. All P-values were derived from two-sided tests. HDP hypertensive disorders of pregnancy, SD standard deviation, BMI body mass index.
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