Fig. 5: Protection against live challenge in TgPVR mice immunised with PV1-SC6b VLPs. | Nature Communications

Fig. 5: Protection against live challenge in TgPVR mice immunised with PV1-SC6b VLPs.

From: Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines

Fig. 5

a Groups of eight mice received either a single or two doses of rsVLPs (orange) produced in yeast (day 0 and 14) prior to challenge on day 35 with 25 × PD50 dose of live PV1 Mahoney and compared to IPV (blue) or a PBS negative control (black). Neutralisation titres prior to boost and on the day of challenge were determined. b Animals were monitored for survival for 14 days following challenge. Error bars represent the Geomean Standard Deviation of the data points. Source data are provided as a Source Data file.

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