Fig. 6: Immunogenicity of rsVLP vaccines in female rats. | Nature Communications

Fig. 6: Immunogenicity of rsVLP vaccines in female rats.

From: Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines

Fig. 6

Dose response in neutralising antibodies following a single immunisation of female Wistar rats in the absence (a) or the presence (b) of adjuvant. Groups of 10 rats received rsVLPs at various multiples of human doses and compared with IPV (blue). Sera were collected 21 dpi and neutralisation titres against the Sabin strains of PV1, PV2 or PV3 determined. VLPs produced from each expression system are depicted as follows: Insect; purple, Mammalian; red, Plant; brown, and Yeast; orange. Error bars represent the Geomean Standard Deviation of the data points. Source data are provided as a Source Data file.

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