Fig. 1: Overview of human telomerase components and hTR structure.
From: Telomerase RNA structural heterogeneity in living human cells detected by DMS-MaPseq
a The conserved ___domain organization of TERT includes the telomerase essential amino-terminal ___domain (TEN), RNA binding ___domain (TRBD), reverse transcriptase ___domain (RT), and carboxy-terminal extension (CTE). A H2A/B dimer comprises one H2A and one H2B protein. b The vertebrate-conserved architecture of hTR includes the template/pseudoknot (t/PK, template sequence shown as red bar), CR4/5, and scaRNA domains. P, paired region. c The hTR template/pseudoknot ___domain (in blue) wraps around TERT and forms the pseudoknot helix P3. TRBD, telomerase RNA binding ___domain. d CR4/5 (in green) adopts an ‘L’ shaped three-way junction and sandwiches TERT TRBD between the P6.1 and P6a/b stems. A dimer of H2A/B binds P5 and P6.1. Structure figures made using PDB 7BG9.
