Fig. 7: Design and MaPseq validation of CR4/5 mutants.
From: Telomerase RNA structural heterogeneity in living human cells detected by DMS-MaPseq
a Canonical CR4/5 secondary structure with mutated nucleotides labeled. b Cryo-EM structure (PDB 7BG9) of CR4/5 with mutated nucleotides highlighted. c Normalized DMS reactivity profiles of clusters predicted by DREEM for overexpressed WT and CR4/5 mutants. Source data are provided as a Source Data file.
