Fig. 7: Antitumor effect in B16F10 tumor model.

a Representative images of Cy5.5@vesicles recruitment in B16F10 tumor-bearing mice. b Ex vivo live imaging of dissected organs and tumor tissues from mice as performed 6 h after intravenous of Cy5.5@vesicles, H: heart, L1: lung, K: kidney, S: spleen, L2: liver, T: tumor. c Quantification of B-10 content in major organs and tumor tissue. d The B-10 ratios of target/nontarget organs at 6 h post intravenous. e Growth curves of individual tumor. f Mean tumor growth curves of mice in each group. g The body weight of animals in each group. h Survival curves of the mice in different groups. i HE staining and j Ki67 immunohistochemical staining and apoptosis testing of tumor tissue sections from experimental groups. Data are displayed as mean ± SD of n = 3 independent measurements in (c) and (d), n = 7 independent measurements in (f) and (g). n.s., not significant, *P < 0.05, **p < 0.01, ****p < 0.0001.