Fig. 7: IPA affects cardiotoxicity through the AhR receptor. | Nature Communications

Fig. 7: IPA affects cardiotoxicity through the AhR receptor.

From: Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice

Fig. 7

A Representative western blots of AhR and CYP1A1 after deficiency of IPA receptor AhR (n = 6). B Relative mRNA levels of Ahr in mouse heart (n = 6). Echocardiographic ejection fraction (EF) (C) and Fractional shortening (FS) (D) (n = 10). E Relative mRNA levels of Bnp (n = 6). F Plasma biomarker assessments revealing levels of cTnT (n = 6). Data are shown as the mean ± SEM and analyzed using unpaired two-tailed Student’s t-test (B) or one-way ANOVA with post hoc tests for others.

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