Fig. 7: Examples of MindGlide segmentations and WMH-Synthseg segmentation.

Examples of segmentation masks acquired using MindGlide and WMH-Synthseg. a Segmentation masks of a scan from our PPMS trial dataset with the segmentation mask acquired using MindGlide on top and the segmentation mask acquired using WMH-Synthseg on the bottom. Areas labelled as lesion are more conservative defined in the MindGlide segmentation mask (olive colour) than in the WMH-Synthseg segmentation mask (black). The red arrow points at an area that is incorrectly defined as lesion by WMH-Synthseg segmentation but not by MindGlide. b Segmentation masks of a scan from our routine clinical dataset (RRMS) with the segmentation mask acquired using MindGlide on top and the segmentation mask acquired using WMH-Synthseg on the bottom. WMH-Synthseg fails to segment an image acquired in anterior-posterior direction with 6 mm thick slices (as seen in the frontal area of the transverse view and multiple areas of the coronal view in (b)). Most segmentation tools are designed to use superior-inferior acquisition directions (as in (a)), while MindGlide allows segmentation of images acquired in any direction.