Fig. 1: Stress shielding-induced delay in osseointegration is associated with low expression of mechanical signaling molecules.
From: Optogenetic activation of mechanical nociceptions to enhance implant osseointegration
a Schematic diagram of mouse tibial implants with Ti6Al4V knee implants (114Gpa) and Ti6Al4V implants with a 25% overall porosity (28Gpa). b, c Methylene blue-acid fuchsin staining and quantitative analysis of bone tissue sections containing implants at two weeks. Scale bars: 10×: 100μm, 40×: 100μm. Data are presented as mean ± SEM (n  =  5 biologically independent experiments). P-values were calculated using Two-tailed Student’s t tests. d Transcriptomic heatmap of peri-implant bone tissue at one week. e Transcriptomic GO enrichment analysis plot of peri-implant bone tissue at one week. f Transcriptomic KEGG enrichment analysis plot of peri-implant bone tissue at one week. g Transcriptomic GSEA plot of peri-implant bone tissue at one week. h The expression of FAK at mRNA levels in peri-implant bone tissue from 0 to 21 days. Data are presented as mean ± SEM (n  =  5 biologically independent experiments). P-values were calculated using Two-tailed Student’s t tests. (BIC%: bone-implant contact percentage, FAK: focal adhesion kinase. h compared to the expression of FAK at mRNA levels of Ti6Al4V group at day 0). Source data are provided as a Source Data file.
