Fig. 2: Differential expression and pathway enrichment results in the amygdala. | Nature Communications

Fig. 2: Differential expression and pathway enrichment results in the amygdala.

From: Large-scale transcriptomic analyses of major depressive disorder reveal convergent dysregulation of synaptic pathways in excitatory neurons

Fig. 2

Analyses are shown for differential (a) gene (b) transcript and (c) splicing results. Volcano plots display log2 (fold change)  on the x-axis and the differential expression association p value on the y-axis. Genes with an FDR-corrected association p value < 0.05 are highlighted in red (upregulation) and blue (downregulation). Selected genes are labeled where possible without cluttering the plot. Above each volcano plot, the most significantly enriched GO ontology pathways are shown. Enrichment analyses were performed using clusterProfiler with a one-sided (right-tailed) hypergeometric test, followed by FDR correction for the number of GO categories. Data for this figure are available in Supplementary Datasets 3 (differential expression) and 4 (GO enrichment).

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