Fig. 5: Role of Eiger in cell competition.
From: Epithelial cell competition is promoted by signaling from immune cells
In (A–C) Clones were generated as in Fig. 1, whereas in (D, E) clones were generated as in (B), but egr was knocked down in hemocytes, using egrRNAi (HMC/KK). F Quantification of the area ratio between twin clones (dark/bright) in discs of the genotypes in A–E. In G–J, clones were induced and hemocytes visualized as in Fig. 3. In I and J discs were manipulated as in (H), but egr was knocked down in hemocytes as in D and E, respectively. K Quantification of the number of hemocytes in wing discs of the genotypes in G–J. L Quantification of the area ratio between twin clones (dark/bright) in discs of the genotypes in G–J. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 by two-sided Mann-Whitney U test. P value = 1.08 × 10−4, 1.90 × 10−4, 5.92 × 10−3, 1.94 × 10−3, 6.66 × 10−3, 2.44 × 10-1, 2.55 × 10-1, 2.69 × 10−2, 4.85 × 10−2, 2.96 × 10-6, 1.44 × 10-1, 5.12 × 10−2, 4.67 × 10-5, and 1.41 × 10−4, respectively. n = 11, 10, 11, 14, 10, 16, 16, 15, and 12 discs for the genotypes in (A), (B), (C), (D), (E), (G), (H), (I), and (J), respectively. Bar = 50 µm. In each box and whisker plot, the box represents the interquartile, spanning from the first quartile to the third quartile, with a white line inside marking the median, and the whiskers show the range of the data, reaching the minimum and maximum values. Source data are provided as a Source Data file.
