Fig. 1: Top level clustering analysis of tumor epithelial cells and characterization of a common tumor cluster. | Nature Communications

Fig. 1: Top level clustering analysis of tumor epithelial cells and characterization of a common tumor cluster.

From: Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression

Fig. 1

A Clustering UMAPs of tumor epithelial cells (N = 8553) extracted from the main dataset color-coded by cluster and annotated according to tumor ID. Cluster 13 (ellipse) is annotated separately due to contributions from multiple tumors. B Cluster composition by patient/tumor. C Table displaying primary and secondary histologic patterns observed in each tumor and percentage of cells within Cluster 13. D Curated dot plot of top differentially expressed genes (DEGs) by tumor cluster. E Serial section immunohistochemistry of MUC4, CA125, and KRT24 in variant tumors (N = 2 of 2 cases). F Representative immunohistochemistry of CA125 in multiple histologic variants. All scale bars = 50 µm. G Preoperative serum CA125 values in bladder cancer patients stratified by tumor grade and histology (Two-way Mann–Whitney U-test, p = 0.007). Quartiles, centers and outliers are shown in the box plot. Source data are provided as a Source data file.

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