Fig. 4: Long-term feeding of Tamogi-take mushrooms attenuates age-related vascular endothelial dysfunction in mice. | npj Aging

Fig. 4: Long-term feeding of Tamogi-take mushrooms attenuates age-related vascular endothelial dysfunction in mice.

From: Long-term intake of Tamogi-take mushroom (Pleurotus cornucopiae) mitigates age-related cardiovascular dysfunction and extends healthy life expectancy

Fig. 4

a Vasorelaxation responses (%) ex vivo to acetylcholine (Ach) (n = 9–11 per group). b Representative western blots (left) and quantitation (right) of 4-HNE-modified protein staining in aorta tissues of indicated groups (n = 6–7 per group). c, d Relative expression of genes associated with inflammation (c) and senescence (d) in aorta tissues from indicated groups (n = 6–7 per group). Values in the control group were set to 1. e Representative western blots (left) and quantitation (right) of Nrf2 (upper) and HO-1 protein (lower) staining in aorta tissues of indicated groups (n = 6–7 per group). In band (d), Hsc70 served as a loading control. Values in the control group were set to 1. Plots for (b–e) present all data points, median and ± SD. Statistical significance was determined by a two-sided unpaired Student’s t test.

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