Fig. 5: Inhibition of CD4 T cell proliferation by H. parainfluenzae-pretreated A253 cells and partial restoration by PD-L1 blockade. | npj Biofilms and Microbiomes

Fig. 5: Inhibition of CD4 T cell proliferation by H. parainfluenzae-pretreated A253 cells and partial restoration by PD-L1 blockade.

From: Salivary dysbiosis in Sjögren’s syndrome and a commensal-mediated immunomodulatory effect of salivary gland epithelial cells

Fig. 5

a CD4 T cell were coculture with H. parainfluenzae-pretreated A253 cells at various bacteria-to-cell ratios. CD4 T cells were isolated from peripheral blood mononuclear cells of healthy donors and anti-Ro-positive pSS patients. One-way ANOVA, p < 0.001; post hoc analysis, ***p < 0.001. b CD4 T cells isolated from healthy donors were cocultured with H. parainfluenzae-pretreated A253 cells at a bacteria-to-cell ratio of 100:1 and PD-L1 blocking antibody was added at various dosages. One-way ANOVA, p = 0.014; post hoc analysis, *p < 0.05. Error bars stand for one standard error.

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