Table 1 Logistic regression analysis of immune cell subsets and clinical variables in predicting pathological complete response (pCR) in breast cancer

LN metastases

Categorical

0.357

0.162–0.784

0.010

0.340

0.133–0.870

0.024

Grade

Categorical

0.200

0.051–0.778

0.020

0.018

0.001–0.349

0.008

PR

Categorical

2.820

0.915–8.688

0.071

15.634

2.398–101.938

0.004

Her-2

Categorical

6.848

2.047–22.909

0.002

4.853

1.089–21.628

0.038

Stage

Categorical

0.645

0.385–1.080

0.095

/

/

/

TILs_Tumor

Continuous

1.394

0.962–2.019

0.079

3.268

1.451–7.362

0.004

CD4⁺_Total

Continuous

1.085

1.003–1.173

0.042

/

/

/

CD8 + _Total

Continuous

1.234

1.077–1.415

0.002

1.414

1.145–1.746

0.001

CD4⁺PD1⁺_Total

Continuous

1.541

1.038–2.286

0.032

/

/

/

CD4⁺TIM3⁺_Total

Continuous

1.238

0.982–1.561

0.071

/

/

/

CD8⁺PD1⁺_Total

Continuous

2.055

1.157–3.648

0.014

/

/

/

CD8⁺TIM3⁺_Total

Continuous

4.934

1.920–12.683

0.001

/

/

/

PD1⁺TIM3⁺_Total

Continuous

4.854

1.915–12.300

0.001

3.739

1.041–8.882

0.003

CD4⁺_Stroma

Continuous

1.059

0.997–1.124

0.063

/

/

/

CD8 + _ Stroma

Continuous

1.001

1.000–1.003

0.007

1.002

1.001–1.004

0.003

CD4⁺PD1⁺_ Stroma

Continuous

1.358

1.029-1.794

0.031

/

/

/

CD8⁺PD1⁺_ Stroma

Continuous

1.407

0.976-2.028

0.067

/

/

/

PD1⁺TIM3⁺_ Stroma

Continuous

3.206

1.466-7.009

0.004

3.739

1.574–8.882

0.003

CD4⁺_ Tumor

Continuous

1.102

1.015-1.196

0.021

/

/

/

CD8⁺_ Tumor

Continuous

1.342

1.137-1.585

0.001

/

/

/

CD4⁺PD1⁺_ Tumor

Continuous

2.533

1.292-4.969

0.007

/

/

/

CD4⁺TIM3⁺_ Tumor

Continuous

1.363

1.074-1.731

0.011

/

/

/

CD8⁺PD1⁺_ Tumor

Continuous

2.865

1.505–5.452

0.001

2.648

2.648–1.313

0.007

CD8⁺TIM3⁺_ Tumor

Continuous

3.234

1.617–6.469

0.001

22.152

3.038–161.538

0.002

PD1⁺TIM3⁺_ Tumor

Continuous

3.881

1.673–9.003

0.002

/

/

/