Table 3 Results of burden analysis at two minor allele frequencies for NBIA genes in PD.

From: Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson’s disease

Gene	Variant Group	MAF	P_AMP	P_UKB	P_Meta	WeightedZ
ATP13A2	All	0.01	0.0904	0.8813	0.2811	0.6518
ATP13A2	All	0.03	0.6599	0.5547	0.7339	−0.6615
ATP13A2	Coding	0.01	0.9272	0.2949	0.6281	−1.0192
ATP13A2	Coding	0.03	0.6622	0.3033	0.5233	−1.2470
C19orf12	All	0.01	0.8789	0.5115	0.8089	1.6650
C19orf12	All	0.03	0.7091	0.5115	0.7305	1.2089
C19orf12	Coding	0.01	1.0000	0.4262	0.7897	1.6592
C19orf12	Coding	0.03	1.0000	0.4262	0.7897	1.6592
COASY	All	0.01	0.5435	0.0832	0.1853	−0.5970
COASY	All	0.03	0.5435	0.0832	0.1853	−0.5970
COASY	Coding	0.01	1.0000	0.0936	0.3154	0.4017
COASY	Coding	0.03	1.0000	0.0936	0.3154	0.4017
CP	All	0.01	0.3392	0.4920	0.4657	1.0089
CP	All	0.03	0.6747	0.4339	0.6524	0.2643
CP	Coding	0.01	0.6615	0.3514	0.5717	0.4431
CP	Coding	0.03	0.6615	0.2169	0.4221	0.1493
DCAF17	All	0.01	0.2382	0.2288	0.3721	−0.9574
DCAF17	All	0.03	0.2382	0.7715	0.8393	0.2144
DCAF17	Coding	0.01	0.1146	0.4555	0.6522	0.8371
DCAF17	Coding	0.03	0.1146	0.7161	0.8917	1.2486
FA2H	All	0.01	1.0000	0.3676	0.7355	−0.4057
FA2H	All	0.03	0.8598	0.3676	0.6801	−0.7388
FA2H	Coding	0.01	0.5816	0.5064	0.6546	−0.9324
FA2H	Coding	0.03	0.5397	0.5064	0.6278	−0.8240
FTL	All	0.01	0.4990	0.8460	0.7862	−0.1314
FTL	All	0.03	0.4990	0.8460	0.7862	−0.1314
FTL	Coding	0.01	0.5583	NA	NA	0.0555
FTL	Coding	0.03	0.5583	NA	NA	0.0555
GTPBP2	All	0.01	0.5471	0.1980	0.3491	−0.7209
GTPBP2	All	0.03	0.2766	0.4241	0.3687	−0.8013
GTPBP2	Coding	0.01	0.0696	0.3808	0.1227	−1.6865
GTPBP2	Coding	0.03	0.6000	0.3712	0.5572	0.7064
PANK2	All	0.01	0.3261	0.8209	0.6205	1.5979
PANK2	All	0.03	0.4622	0.9000	0.7809	0.8418
PANK2	Coding	0.01	0.7875	0.0507	0.1684	0.3729
PANK2	Coding	0.03	0.7875	0.0507	0.1684	0.3729
PLA2G6	All	0.01	0.7644	0.2124	0.4575	1.3405
PLA2G6	All	0.03	0.7661	0.3815	0.6518	0.4891
PLA2G6	Coding	0.01	0.9007	0.3588	0.6882	−0.9407
PLA2G6	Coding	0.03	0.8603	0.6690	0.8935	0.1710
VAC14	All	0.01	0.2814	0.4390	0.3819	−1.2446
VAC14	All	0.03	0.3986	1.0000	0.7653	−0.3362
VAC14	Coding	0.01	0.3683	0.7708	0.6414	0.0051
VAC14	Coding	0.03	0.3683	0.8155	0.6616	−0.0728

MAF Minor Allele Frequency, P_AMP P value in AMP_PD cohort, P_UKB P value in UKB cohort, P_Meta P value in meta analysis, Weighted Z Weighted Z Statistic.

Back to article page

Table 3 Results of burden analysis at two minor allele frequencies for NBIA genes in PD.

Search

Quick links