Fig. 3: Protein pathways and cell types. | npj Parkinson's Disease

Fig. 3: Protein pathways and cell types.

From: Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease

Fig. 3

a STRING interactions of the 25 proteins and LRRK2 (red arrow). b EnrichGO of 6138 SomaScan7K genes with recognized unique entrez ID as background and 26 genes of interest (25 proteins and LRRK2). Biological process (BP) and cellular component (CC) are shown. c DisGeNET gene-disease enrichment of 26 genes and 6138 SomaScan7K genes. The top five disease-gene connections are shown. d Brain cell-type fold-change (FC) barplot using 5709 CSF SomaScan7K proteins with brain cell-type data and 25 proteins. *** is FC > |3.7| (P = 3.45 × 10−5) and * is FC > |3.0 | . e Cellular pathways. Pathway involvement of the 25 LRRK2-associated proteins in the endosome, Golgi apparatus, endoplasmic reticulum (ER), nucleus, mitochondrion, cytoplasm, plasma membrane, extracellular space, and lysosome. A large proportion of LRRK2-associated proteins are involved (or enriched) in the endolysosomal pathway. *Most likely involved. +Druggable protein target. Cell structure images are from Bioicons.

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