Table 3 HR (95% CI) of Parkinson’s disease according to social isolation stratified by genetic risk score for Parkinson disease

From: Social isolation and the risk of Parkinson disease in the UK biobank study

 

Social isolation

Genetic risk score for Parkinson disease

Least isolated

Moderately isolated

Most isolated

P-trend

Low ( < median)

 Cases/person-years

391/547,230

325/466,031

123/154,158

 

 HR (95% CI)

1.00

0.98 (0.84–1.13)

1.07 (0.86–1.31)

0.73

High ( ≥ median)

 Cases/person-years

524/507,908

438/429,004

180/139,955

 

 HR (95% CI)

1.00

1.01 (0.89–1.15)

1.28 (1.07–1.52)

0.02

 P-interaction

0.51

   
  1. HRs were adjusted for age at recruitment (continuous, years), sex (men, women), education (college or university degree, others), Townsend Deprivation Index (continuous), body mass index (continuous, kg/m2), alcohol intake (never or special occasions, monthly to weekly, daily), smoking status (never, past, current), sleep duration (≤6, 7–8, ≥9 hours/day), and history of hypertension, cardiovascular disease, diabetes, cancer, chronic kidney disease (yes, no), genetic batches and the first 10 principal component analysis.
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