Fig. 1: The CT-rich SNCA haplotype 4 impacts gene expression in the frontal cortex. | npj Parkinson's Disease

Fig. 1: The CT-rich SNCA haplotype 4 impacts gene expression in the frontal cortex.

From: Characterizing a complex CT-rich haplotype in intron 4 of SNCA using large-scale targeted amplicon long-read sequencing

Fig. 1

a Transcript model of SNCA with blue-shaded significantly differentially expressed transcript, ENST00000508898.5. Pink box denotes CT-rich SNCA haplotype ___location in intron 4. b Box plot for haplotype 4 QTL from NABEC CAGE-seq data for CAGE transcription start site (CTSS) chr4:89836178-89836272. CTSS expression normalized through quantile regularization and changed to normal distribution. Expression of CTSS decreases with presence of haplotype 4. Center line represents the median and error bars indicate the maximum and minimum quartiles.

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