Fig. 3: circRNAs change over the course of the disease and can be leveraged diagnostic biomarkers.

A Line plots showing trajectories of circRNA abundances for the top three significant circRNAs in longitudinal analysis, as well as the nine high-confidence circRNAs from cross-sectional analysis; B Whisker plot showing ROC AUC values with 90% confidence interval evaluating the ability of three combination of circRNAs to distinguish between PD participants and healthy controls or at-risk participants and healthy controls.