Fig. 6: MJF-14 PLA signal is not specific for α-synuclein in mouse models. | npj Parkinson's Disease

Fig. 6: MJF-14 PLA signal is not specific for α-synuclein in mouse models.

From: MJF-14 proximity ligation assay detects early non-inclusion alpha-synuclein pathology with enhanced specificity and sensitivity

Fig. 6

a Comparison of MJF-14 PLA signal in α-synuclein transgenic (ASO) and α-synuclein knockout (ASKO strain #1) mice, using PLA probes and detection kits from Duolink (Sigma). b Similar comparison of MJF-14 PLA signal as in (a) but using PLA probes and detection kits from Navinci. c MJF-14 PLA signal in a different α-synuclein knockout strain (ASKO strain #2), compared with WT, and triple α-/β-/γ-synuclein knockout mice (TKO). d MJF-14 PLA signal in α-/β-synuclein double knockout mice (A/B-KO). All scale bars = 20 µm.

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