Fig. 1: Group comparisons in bilateral DTI-ALPS index and correlations with clinical variables.

Left Group differences in bilateral DTI-ALPS index. Right Significant correlations between bilateral DTI-ALPS index and age, UPSIT-40 scores, SDMT and semantic fluency. Data corresponding to iRBD are presented in red, whereas data for HC are presented in blue. Abbreviations: DTI-ALPS, diffusion tensor imaging along the perivascular space; HC, healthy controls; iRBD, isolated Rapid-Eye-Movement disorder; r, correlation coefficient of the iRBD group; SDMT, Symbol-Digit Modality Test- oral version; p, p-value for correlations in the iRBD group; UPSIT-40, University of Pennsylvania Smell Identification Test, 40 items. Graphs were obtained using the package ggplot2 (Wickham, 2016).