Fig. 3: Intra-arterial injection can deliver mitochondria in the ischemic brain parenchyma.
From: Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation
Mice were stroked with middle cerebral artery occlusion, injected intraarterially and their brains were cryo-sectioned and stained with DAPI (blue). a and b Stroked brain injected with exogenous mitochondria pre-labeled with MitoTracker (red), c Stroked brain injected with PBS. Both animals were injected in the common carotid artery following middle cerebral artery occlusion. Images were acquired in the striatum with confocal microscopy. Mitochondria crossed the blood–brain barrier and localized throughout the parenchyma. Occasionally, mitochondria were found deposited in the blood vessels (white arrow). b Higher magnification of a mitochondrial deposit shown in a. a Scale bar, 50 μm. b, c Scale bar, 25 μm.
