Fig. 3: Infarction susceptible protein classes respond to cell therapy.
From: Cardiopoietic stem cell therapy restores infarction-altered cardiac proteome
Categorical impact was assessed for 33 functional classes into which proteins were allocated, with radial graphs plotting changes induced by myocardial infarction without (MI vs. Ctrl; upregulated in a, downregulated in b) or with cardiopoietic cell therapy (MI + CP vs. Ctrl; upregulated in c, downregulated in d). Radial displacement (red projection) indicates intra-class percentage differing from controls (Categorical Δ, %). Blue circles represent total proteome change (Total Δ, %). Proteins upregulated by infarction were reduced for most categories (26% overall) by cell therapy (a versus c), and likewise for categories downregulated by infarction (b versus d), which reduced 46.5% overall. For each graph a–d, n indicates number of proteins changed (>2-fold, p < 0.01). Functional categories are arrayed alphabetically, with identities and number of proteins listed.
