Fig. 1: Therapeutic workflow for muscle stem cells in regenerative medicine utilizing multiple convergent advances.
From: Towards stem cell therapies for skeletal muscle repair
(Left) Muscle stem cells (MuSCs) prospectively isolated from muscle tissue or derived from differentiation of induced pluripotent stem cells (iPSCs). (Middle) Ex vivo expansion of MuSCs in optimized culture platform that mimics in vivo microenvironment supporting self-renewal. (Right) Delivery of undifferentiated MuSCs into diseased/damaged muscle with biometric scaffold boosting transplantation efficiency.
