Fig. 4: In vivo experiment. | npj Regenerative Medicine

Fig. 4: In vivo experiment.

From: Multifunctional injectable microspheres for osteoarthritis therapy via spatiotemporally modulating macrophage polarization and inflammation

Fig. 4

a Timeline of administration of rat osteoarthritis. b 3D micro-CT of rat bone and joint reconstruction in the double-layer microsphere group containing two drugs and all control groups and separated trabecular bone images. c In the 6th and 12th weeks of treatment, the quantified data of the micro-CT analysis. d Tracking and monitoring of the difference in the circumference of the bilateral joints of the rats in each treatment group during the treatment, n = 3. e Analysis of the content of cytokines PGE2, TNF-α and IL-1β in the extracted synovial fluid. Data are presented as means ± SD in (c, d).

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