Fig. 1: Significantly altered functional connectivity clusters (FC clusters) identified in the first-episode schizophrenia (FES) patients compared to healthy controls in the primary and validation dataset.

a Voxels showing the largest number of voxel-level functional connectivity differences in FES patients in the primary dataset. The color bar represents the measure of association (MA) which is the number of significantly altered functional connectivities relating to each voxel. b Significantly altered FC clusters identified in FES patients in the primary dataset (33 FC clusters in total, details see Supplementary Table 2). The color of the 3 circles (from inside to outside) denotes: the number of deceased links; the number of increased links; the 94 different automatic anatomical labeling (AAL2) regions. Red lines mean that patients have a higher mean functional connectivity than controls, and blue lines indicate the opposite. The anatomical abbreviations in the figure are shown in the Supplementary Table 1. c 16 of the 33 significantly altered FC clusters were replicated in an independent validation dataset, involving the left inferior frontal triangular gyrus, bilateral thalamus, the left middle temporal lobe and the right superior temporal lobe.