Fig. 1: Study design and task procedures.

A Experimental workflow diagram showing screening for schizotypy and allocation to treatment groups for selected volunteers. B Demographic data, including treatment group, age, gender, and level of schizotypy in the MID task. C Design of the MID task. Participants were presented with a cue predicting either monetary gain, loss, or no change, and asked to press a button in response to a following target as fast as possible. There were three types of trial: possible reward, possible punishment and neutral, depending on whether participants responded on time to the target. D ROI used in the MID task. Masks were created in bilateral striatum, bilateral insula and mOFC. All masks were 10-mm radius spheres based on previously reported coordinates from the meta-analysis of Liu et al.⁴¹. Specific coordinates of ROI used for the anticipatory phase were 38 20 –8, and -32 18 –6 for right and left insula, 12 10 –4 and –12 10 –6 for right and left striatum, and 2 50 –16 for mOFC. For the outcome phase, coordinates were 36 22 –8 and –28 24 –8 for right and left insula, 12 10 –6 and 10 8 –4 for right and left striatum and –2 56 –6 and 2 48 –14 for mOFC. ASL arterial spin labeling, ETB emotional test battery, MID monetary incentive delay, mOFC medial orbital frontal cortex, RSC resting state connectivity, SPQ Schizotypal Personality Questionnaire, VS ventral striatum.