Fig. 2: Main effects of MID task and treatment on BOLD response. | Schizophrenia

Fig. 2: Main effects of MID task and treatment on BOLD response.

From: Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy

Fig. 2

A Main effects of MID task on ROI BOLD signals in anticipation and outcome phases in VS, insula and mOFC. B Effects of treatment with ulotaront, amisulpride or placebo on BOLD signals in VS, insula and mOFC ROIs during anticipation of loss, and on left insula responses in win trials in anticipation and outcome phases. C High schizotypes are sensitive to loss anticipation and this is reversed by ulotaront but responses to loss outcomes are similar in HS and LS and ulotaront enhanced these responses. Whole-brain SVC analysis with FWE p < 0.05 correction. BOLD blood oxygen level‒dependent, FWE family-wise error, HS high schizotypy, LS low schizotypy, MID monetary incentive delay, mOFC medial orbital frontal cortex, ROI region of interest, SVC small volume correction, VS ventral striatum. Error bars are standard errors of the mean.

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