Fig. 4: Durability of neutralizing antibody responses elicited by SARS-CoV-2 S6P-HBsAgs. | npj Vaccines

Fig. 4: Durability of neutralizing antibody responses elicited by SARS-CoV-2 S6P-HBsAgs.

From: Self-assembling SARS-CoV-2 spike-HBsAg nanoparticles elicit potent and durable neutralizing antibody responses via genetic delivery

Fig. 4

The sera from mice immunized with DNA encoding SARS-CoV-2 S2P(1-1206), S6P(1-1206), S6P-12-HBsAg or S6P-16-HBsAg were tested from week 22 to week 45. The ID50s against WA1 pseudovirus obtained from the pooled serum of each group were shown for the 10, 2 and 0.4 µg doses. The bars were colored in beige, green, red and blue for S2P(1-1206), S6P(1-1206), S6P-12-HBsAg and S6P-16-HBsAg, respectively. The graphs for weeks 22, 30 and 45 were shown in different panels. The dashed lines indicate detection limit of 40. The ID50s below detection limit were set as 20. The error bars represent standard deviation from triplicate measurements.

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