Fig. 5: Clathrin-mediated endocytosis inhibitors impede SARS-CoV-2 spike-induced syncytium formation. | Nature Biomedical Engineering

Fig. 5: Clathrin-mediated endocytosis inhibitors impede SARS-CoV-2 spike-induced syncytium formation.

From: High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2

Fig. 5

a–d, GFP-split complementation system assay was applied using A549-ACE2-GFP1–10 (a,b) and Vero E6-GFP1–10 (c,d) as receiver cells. The HEK293T-GFP-11 sender cells used express WT D614G spike. Representative images are shown. Data shown are mean ± s.d. (n = 6 biological replicates). P values indicated were compared with DMSO-treated control. Statistical significance was determined using one-way ANOVA. ****P < 0.0001. Scale bars, 200 μm.

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