Extended Data Fig. 8: Overview of MRI T1 and \({{\rm{T}}}_{2}^{\ast }\) values for the cases presented in the figure summarizing the findings of the study. | Nature Biomedical Engineering

Extended Data Fig. 8: Overview of MRI T1 and \({{\rm{T}}}_{2}^{\ast }\) values for the cases presented in the figure summarizing the findings of the study.

From: Water and ions binding to extracellular matrix drives stress relaxation, aiding MRI detection of swelling-associated pathology

Extended Data Fig. 8

MRI parameters mapped in FRESH, HYPO, ISO, and ISO-PEG conditions for a, T1 values and b, \({{\rm{T}}}_{2}^{\ast }\) values. The ISO + PEG condition shown here includes samples of both 100 kPa and 200 kPa osmotic pressure applied by PEG to ECM samples in ISO solution. Dotted lines indicate the mean value of T1 or \({{\rm{T}}}_{2}^{\ast }\) in an in vitro case. Value ranges from first to third quartile [Q1–Q3] are presented for each condition and MRI parameter. P values were calculated using Brown-Forsythe and Welch ANOVA tests with Dunnett’s T3 multiple comparisons tests. Analyses were conducted in a, for n = 8–12 biological samples, and in b, for n = 7–12 biological samples. Box plot information: box limits show 25th and 75th percentiles, box middle lines show medians, and whiskers show minimum and maximum values.

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