Extended Data Fig. 10: Model illustrating the proposed role of DmTMEM63-mediated lysosomal mechanotransduction.
From: Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels
Left, the lysosomal membrane harbors the DmTMEM63 protein, a mechanosensitive cationic channel. Right, the interplay between DmTMEM63 channel activity and lysosomal dynamics. The lysosomal morphological remodeling alters the membrane curvature and surface tension (i) and cytoskeletal elements, such as kinesin-microtubule complex that drives lysosomal tubulation23, exert mechanical forces on the lysosomal membrane (ii). These changes in mechanical state of the lysosomal membrane may activate the DmTMEM63 channel and cause lysosomal Ca2+ efflux which in turn regulates lysosomal remodeling and mobility. The model was created with BioRender.com.
