Extended Data Fig. 2: scRNA-seq of BM cells in naïve mice and different TiBA tumor-bearing models.
From: Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions
a, Diagram showing FACS-sorting of BM cells from Sham and TiBA tumor-bearing mice for scRNA-seq. b, Heatmap of top 5 markers expression of BM cell clusters in the BALB/c dataset. c, Heatmap of top 5 markers expression of BM cell clusters in the C57BL/6 dataset. d, Feature plots show the expression of early B cell marker genes across BM cell clusters. e, Diagram showing the firefly-luciferase/GFP-labeled 4T1 cells were transplanted into the mammary fat pad (MFP). f, Representative image showing negative luc-signals at different bones. g, Heatmaps of log10 fold change in the percentage of various B cell subsets in BM of tumor-bearing mice compared with Sham. n = 3 mice/group.
