Fig. 1: Glycosylated spike RBD ‘down’ and ‘open’ conformations.
From: A glycan gate controls opening of the SARS-CoV-2 spike protein
a, The SARS-CoV-2 spike head (grey) with glycans (dark blue) as simulated, with the stalk ___domain and membrane (not simulated here, but shown as transparent for completeness). RBD shown in cyan, RBM in pink. b,c, Side view of the RBDdown (shielded, b) and RBDopen (exposed, c). d,e, Top view of the RBMclosed (shielded, d) and RBMopen (exposed, e). Composite image of glycans (dark blue lines) shows many overlapping snapshots of the glycans over the microsecond simulations.
