Extended Data Fig. 6: Characterization of dextran sulfate/vismodegib nanoparticles. | Nature Materials

Extended Data Fig. 6: Characterization of dextran sulfate/vismodegib nanoparticles.

From: P-selectin-targeted nanocarriers induce active crossing of the blood–brain barrier via caveolin-1-dependent transcytosis

Extended Data Fig. 6

(a) Dynamic light scattering characterization of DexVis nanoparticles. (b) HPLC quantification of vismodegib in DexVis and FiVis nanoparticle formulations from three preparations, and a standard curve of vismodegib. (c) Encapsulation efficiencies of FiVis and DexVis nanoparticles. Data are means ± SEM. n = 3 samples from independent experiments; ns, not significant (two-tailed t test). (d) Drug release profile of FiVis and DexVis nanoparticles incubated at 37 °C (25% adult bovine serum in PBS). Evaluated by HPLC quantification of vismodegib released into solution over time. Data are means ± SEM. n = 3 samples from independent experiments.

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